Phage based vaccine: A novel strategy in prevention and treatment

The vaccine was first developed in 1796 by a British physician, Edward Jenner, against the smallpox virus. This invention revolutionized medical science and saved lives around world. production of effective vaccines requires dominant immune epitopes to elicit robust response. Thus, applying bacteriophages has attracted attention many researchers because their advantages design development. Bacteriophages are not infectious humans unlikely bind cellular receptors activate signaling pathways. Phages could both humoral immunity, which is another goal an design. Also, phages act as adjuvant, along with antigens, induce Phage-based can also be administered orally stability gastrointestinal tract, contrast common vaccination routes, intradermal, subcutaneous, or intramuscular. review presents current improvements phage-based applications preventive therapeutic vaccines.